You are currently viewing Trulicity Vs Mounjaro: What’s The Difference And Which Is Better For Weight Loss?

Trulicity Vs Mounjaro: What’s The Difference And Which Is Better For Weight Loss?

Revolutionizing the landscape of medical weight loss programs, the integration of diabetes medications has heralded a new era in combating obesity. The astounding efficacy of these blood sugar control drugs in promoting sustainable weight loss has captivated the medical community and patients alike. Among the latest comparisons in the realm of type 2 diabetes mellitus medications are Mounjaro® (tirzepatide) and Trulicity® (dulaglutide), both classified as GLP-1-type drugs. Though their common goal is to treat type 2 diabetes, their unique mechanisms of action set them apart in their ability to facilitate weight loss as part of a comprehensive metabolic reset, guided by healthcare professionals.

Administered through weekly injections and manufactured by Eli Lilly, Mounjaro and Trulicity target the GLP-1 receptors, known for their appetite-suppressing effects, ensuring a sensation of fullness that endures longer. While both medications are prescribed off-label for weight loss, it is crucial to discern their subtle differences and determine which one holds the key to unlocking an individual’s weight loss journey.

In this article, we embark on a comparative exploration of Mounjaro vs. Trulicity, seeking to unravel the nuances of their actions, untangle the web of similarities and disparities, and ultimately empower readers to make an informed decision about the most suitable option for their weight loss endeavors.

What Is Trulicity?

Trulicity, also known by its generic name dulaglutide, is a once-weekly injectable medication designed specifically to treat type 2 diabetes. Classified under the class of drugs known as GLP-1 receptor agonists, Trulicity operates by stimulating the release of insulin while simultaneously reducing glucose production in the liver. By doing so, it effectively lowers blood sugar levels, bringing them within a healthier range. Moreover, Trulicity’s unique mechanism of action can lead to additional benefits, such as promoting weight loss.

Manufactured by the reputable US-based pharmaceutical company Eli Lilly & Co, Trulicity has been one of the pioneering GLP-1 medications to receive FDA approval for patients suffering from type 2 diabetes. Administered via a once-weekly subcutaneous injection, the medication is conveniently packaged in a prefilled autoinjector, simplifying the treatment process for patients. Calibrate doctors often prescribe Trulicity, among other GLP-1 medications, as a crucial component of Calibrate’s Metabolic Reset program, emphasizing its effectiveness in managing blood sugar and supporting weight loss goals.

Trulicity Vs Mounjaro: What's The Difference And Which Is Better For Weight Loss?

Trulicity’s dosages are incrementally increased over time, starting at 0.75mg and gradually titrating up to a weekly dosage of 4.5mg. The medication’s FDA approval in 2014 came after extensive data analysis from six distinct clinical trials involving a total of 3,342 patients. Notably, the outcomes demonstrated that treatment with dulaglutide led to more significant reductions in A1c levels compared to the placebo, solidifying Trulicity’s position as a reliable and effective treatment option for individuals with type 2 diabetes.

Does Trulicity Work For Weight Loss?

In a 52-week clinical trial involving 1,842 patients with an average BMI of 34.2, Trulicity® (dulaglutide) demonstrated its potential to promote weight loss when combined with lifestyle changes, such as adjustments to food intake and exercise. The trial evaluated three different doses of Trulicity®, namely 1.5 mg, 3.0 mg, and 4.5 mg.

Remarkably, at the 36-week mark, all three doses of Trulicity® resulted in significant reductions in body weight compared to the baseline measurements. Notably, patients with higher baseline BMIs who were given the higher doses of dulaglutide experienced the most substantial weight loss. These findings underscore the effectiveness of Trulicity® in supporting weight loss efforts when used in conjunction with lifestyle modifications, making it a promising option for individuals seeking to achieve their weight loss goals.

The effectiveness of Trulicity® in promoting weight loss varies on an individual basis and is influenced by various factors, including genetics and medical history. These same factors also influence an individual’s tolerance to dulaglutide or other GLP-1 medications. It is important to note that serious adverse events with Trulicity® are rare, adding to its overall safety profile.

Overall, while Trulicity® is not a dedicated weight loss medication, its potential weight loss effects make it a noteworthy option for individuals seeking to manage their weight alongside their diabetes or other health conditions.

What Is Mounjaro?

Mounjaro is an innovative oral medication designed to effectively manage type 2 diabetes, offering a promising solution for individuals struggling with the condition. Classified as an SGLT2 inhibitor, Mounjaro operates by obstructing the reabsorption of glucose in the kidneys, leading to an increased excretion of glucose through urine. By this mechanism, the medication efficiently lowers blood sugar levels, bringing them under control, while also presenting potential benefits for cardiovascular health.

Trulicity Vs Mounjaro: What's The Difference And Which Is Better For Weight Loss?

Recently receiving FDA approval in May 2022, Mounjaro, with its generic name tirzepatide, is a cutting-edge dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Manufactured by Eli Lilly & Co., this groundbreaking drug is making waves in the treatment of type 2 diabetes due to its unique design. Unlike other medications within the GLP-1 receptor agonist family, Mounjaro showcases an exceptional dual-action feature, imitating the actions of two vital incretin hormones involved in controlling blood glucose levels: GLP-1 and GIP.

This combination of GLP-1 and GIP receptor agonists in a single drug has shown promising potential in improving the drug’s efficacy, as highlighted in an article published in Diabetes Therapy. The co-infusion of GLP-1 and GIP demonstrates a synergistic effect, resulting in significantly increased insulin response and glucagonostatic (glucagon stabilizing) response compared to the administration of each hormone individually. This remarkable finding implies that Mounjaro’s unique approach may offer advantages in blood sugar control beyond what GLP-1 alone can achieve.

For patients commencing Mounjaro treatment, the recommended starting dosage is 2.5 mg, delivered through a convenient once-weekly subcutaneous injection using a prefilled pen device. Over the course of four weeks, doses may be gradually increased in 2.5 mg increments, as tolerated, up to a maximum of 15 mg once weekly. Healthcare providers play a vital role in setting and monitoring these doses, ensuring that patients achieve their desired blood sugar, weight loss, and metabolic health goals effectively and safely. As a groundbreaking and first-in-class medicine, Mounjaro offers a new avenue of hope for those striving to manage type 2 diabetes and improve their overall well-being.

Does Mounjaro Work For Weight Loss?

In the recent SURMOUNT-1 clinical trial, participants experienced significant weight loss with Mounjaro® (tirzepatide) over a 72-week period. Those on a 5 mg dose saw a weight loss of 15.0%, while participants on a 10 mg dose achieved a weight loss of 19.5%. Impressively, those taking the highest dose of 15 mg experienced the most substantial weight loss, with an impressive 20.9% reduction. In contrast, participants who received a placebo only experienced a modest weight loss of 3.1%.

Alongside its remarkable impact on weight, tirzepatide also proved highly effective in reducing hemoglobin A1C levels. These findings highlight the promising potential of Mounjaro® in managing both weight and blood sugar levels, making it a noteworthy option for individuals with type 2 diabetes and those seeking to address their weight-related health concerns.

Trulicity Vs Mounjaro: What’s The Difference?

When considering the key distinctions between once-weekly subcutaneous tirzepatide (Mounjaro®) and dulaglutide (Trulicity®), research thus far points to Mounjaro® as the frontrunner in terms of its efficacy in reducing A1C levels and promoting weight loss.

A notable study conducted in 2018 directly compared tirzepatide with dulaglutide, revealing that tirzepatide exhibited significantly superior effects in glucose control and weight reduction compared to dulaglutide. Notably, the safety and tolerability profile of tirzepatide were found to be comparable to those of dulaglutide, and the drug was generally well-tolerated by participants.

Adding to the evidence base, an ongoing clinical trial known as SURPASS-CVOT aims to elucidate tirzepatide’s potential to mitigate cardiovascular risk. This phase 3, randomized, double-blind cardiovascular outcomes trial will assess tirzepatide for both non-inferiority and superiority against dulaglutide. Meanwhile, the Trulicity® website already states that dulaglutide may be used in adults with type 2 diabetes to reduce the risk of major cardiovascular events, such as heart attack or stroke, in individuals with heart disease or multiple cardiovascular risk factors.

One of the key differences between Mounjaro® and Trulicity® lies in their receptor targeting. Mounjaro® targets both the GLP-1 and GIP receptors, while Trulicity® focuses solely on the GLP-1 receptor. The GIP receptor is a hormone that plays a vital role in meal digestion, working in tandem with GLP-1 to enhance insulin secretion, regulate blood glucose levels, and assist in fat metabolism. Furthermore, the combination of GLP-1 and GIP appears to slow down meal digestion, leading to increased feelings of fullness and satisfaction for a more extended period. The synergy between GLP-1 and GIP in managing insulin levels suggests that Mounjaro® may present a more effective treatment option for obesity compared to Trulicity®.

As the research continues to unfold and the SURPASS-CVOT trial progresses, a clearer understanding of tirzepatide’s cardiovascular benefits and overall efficacy in managing type 2 diabetes and promoting weight loss will come to light. The comparison between Mounjaro® and Trulicity® showcases the promise of these medications in revolutionizing diabetes management, offering hope for patients seeking effective solutions to improve their health and well-being.

Trulicity Vs Mounjaro: Which One Is Better For Weight Loss?

The battle of Mounjaro vs. Trulicity has ignited excitement among individuals seeking effective weight loss treatments. While both medications offer compelling options, the key lies in selecting the one that best aligns with your unique needs and goals. Entrusting professional healthcare providers with this decision ensures a personalized approach to your weight loss journey, taking into account factors such as medical history, preferences, and individual responses to treatment.

At first glance, Mounjaro and Trulicity appear remarkably similar, making it challenging to discern the better choice. Let’s delve into each medicine, examining their essential aspects and comparing their impacts on weight loss:

Application Method:

Both Mounjaro and Trulicity are administered through subcutaneous injections, using user-friendly injectable pens with adjustable dosages. These injections are relatively painless, making self-administration convenient and hassle-free. In case you feel uncomfortable applying the injection yourself, a family member or friend can assist you. Detailed instructions come with the pen, and your healthcare provider will walk you through the process, ensuring correct usage. Recommended injection sites include the abdomen, thighs, and outer side of the upper arms, with rotation between spots to prevent irritation.


Both medications are taken once a week on the same day, starting with low doses that your doctor will gradually increase every four weeks. This personalized dosing allows for an optimized response to the treatment, with some individuals experiencing weight loss early on, while others may require higher doses for desired outcomes. However, Mounjaro and Trulicity significantly differ in dosage. Trulicity starts at 0.75mg per week, reaching a maximum of 4.5mg weekly. In contrast, Mounjaro’s initial dose is 2.5mg per week, with the potential to escalate up to a maximum of 15mg weekly.

Active Compounds and Effectiveness:

Trulicity’s active compound is dulaglutide, while Mounjaro’s is tirzepatide. Both medications are highly effective; however, Mounjaro holds a promising advantage due to its dual action on GLP-1 and GIP receptors. This unique combination enhances its effectiveness, setting it apart from Trulicity. Clinical trials with Mounjaro revealed an average weight loss of 5% with the lowest dose (2.5mg) and an impressive 20% with the highest dose (15mg). Trulicity’s highest dose (4.5mg) resulted in an average weight loss of 5% of body weight.

Program Eligibility Requirements:

Both Trulicity and Mounjaro target individuals with obesity or overweight concerns. Eligibility typically involves having a body mass index (BMI) of 30 or higher or a BMI of 27 or higher with weight-related conditions like diabetes or heart disease. To determine your eligibility for these programs, consult a weight loss doctor for personalized assessment.

Side Effects and Drug/Disease Interactions:

Common side effects for both Mounjaro and Trulicity include nausea, vomiting, diarrhea, stomach pain, and constipation. While these effects are generally manageable, some rare but severe adverse reactions may occur, such as pancreatitis, hypoglycemia (low blood sugar), and kidney problems. Disclosing your medical history to your doctor is crucial, as certain conditions or medications may influence the suitability of these drugs. Furthermore, combining Mounjaro or Trulicity with alcohol may exacerbate side effects, underscoring the importance of adhering to your healthcare provider’s recommendations and avoiding any medication adjustments without their guidance.

Which one is better for weight loss?

Mounjaro and Trulicity are both effective for weight loss, but Mounjaro is more effective. Mounjaro also has a higher maximum dose, which allows for more flexibility in treatment. However, both medications have similar side effects, so it is important to talk to your doctor about which one is right for you.

When it comes to weight loss, the choice between Mounjaro and Trulicity is not easy. Your doctor can help you decide based on your individual needs and goals. Remember to follow your doctor’s advice and not make any changes to your medication without talking to them first. With their guidance, you can find the best option to support your weight loss journey in a safe and effective way.


The comparison between Mounjaro® and Trulicity® reveals two remarkable medications that offer promising solutions for weight loss and type 2 diabetes management. Both drugs have shown efficacy in promoting weight loss, with Mounjaro® demonstrating an edge in its dual-action approach and higher dosage options. Trulicity®, on the other hand, has proven benefits in cardiovascular risk reduction, making it a valuable choice for individuals with heart disease or multiple cardiovascular risk factors.

While Trulicity® may not be specifically designed as a weight loss drug, it can still aid in weight reduction as a beneficial side effect. Similarly, Mounjaro® has garnered attention for its significant weight loss effects, particularly evident in clinical trials, along with its capacity to improve hemoglobin A1C levels.

Ultimately, the decision between Mounjaro® and Trulicity® depends on individual factors, including health history, goals, and medication tolerance. The guidance of healthcare providers is indispensable in tailoring a personalized treatment plan that addresses unique needs and optimizes outcomes.

As research continues to evolve and new clinical trials emerge, the landscape of diabetes medications and weight loss treatments will continue to advance. With ongoing advancements in medical science, individuals can have greater hope in finding effective and safe solutions to improve their overall health and well-being.


Meet Dinky, a Ramapo College of New Jersey alumnus who traded in her pen and notebook for a barbell and stopwatch. Dinky has been flexing her writing muscles for over four years as a journalist. She’s now bringing her expertise to, where she covers the latest and greatest in fitness trends, health, and lifestyle topics. But Dinky doesn’t just write about fitness – she lives it. She’s a regular at the gym and has a passion for CrossFit and bodybuilding competitions, making her the ultimate insider in the fitness industry. So whether you’re looking for workout inspiration, the latest supplement reviews, or coverage of the biggest competitions, Dinky’s got you covered.

Leave a Reply